Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic
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منابع مشابه
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic
Abnormal presence of autophagic vacuoles is evident in brains of patients with Parkinson's disease (PD), in contrast to the rare detection of autophagosomes in a normal brain. However, the actual cause and pathological significance of these observations remain unknown. Here, we demonstrate a role for mitochondrial metabolism in the regulation of the autophagy-lysosomal pathway in ex vivo and in...
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5 6 Boa Kim, Ji-Seok Kim, Yisang Yoon, Mayra C. Santiago, Michael D. Brown, and 7 Joon-Young Park 8 9 Department of Kinesiology, College of Health Professions and Social Work, Temple University, 10 Philadelphia, Pennsylvania; Department of Physiology, School of Medicine, Georgia Health 11 Sciences University, Augusta, Georgia; and Department of Kinesiology and Nutrition, College 12 of Applied H...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2012
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/dds309